Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 504 6082390

Research Article - Biomedical Research (2017) Volume 28, Issue 2

Preparation and characterization of a scaffold complex based on o-hydroxyethyl chitosan

This study aims to prepare a scaffold complex based on O-hydroxyethyl chitosan (O-HECS) for tissue engineering. The characteristics of the scaffold complex were investigated. Chitosan was made to react with ethylene oxide to obtain water-soluble O-HECS. Body-sealing tube polymerization was conducted with stannous octoate as the catalyst and water-soluble O-HECS as the initiator. D,Llactide ring-opening polymerization was stimulated to prepare water-soluble O-hydroxyethylchitosangrafted polylactic acid (O-HECS-g-PLA). This copolymer was characterized by X-ray diffraction, infrared spectroscopy, scanning electron microscopy and dissolution experiment. A water-soluble OHECS/ polylactic acid copolymer with increased performance was successfully prepared. Water-soluble O-HECS-g-PLA was obtained by chemical modification method. The copolymer has a good mesh structure and porosity and can be used as a drug eluting scaffold. In addition, this copolymer is soluble in certain common organic solvents, which is beneficial for further application in tissue engineering.

Author(s): Xiaofeng Li, Shengli Liu, Weihong Xi, Yuanfei Xiong, Yu Xie, Chao Liu

Abstract Full Text PDF