Journal of Brain and Neurology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Short Article - Journal of Brain and Neurology (2019) Volume 2, Issue 1

Potential synergism of Caffeic acid Phenethyl ester And Dasatinib in C6 Glioma cell Model: Adumbrating the Molecular mechanism

 Gliomas are one of the most invasive, highly recurrent, heterogeneous cancers resistant to most of the current treatment regimes and hence almost incurable. Accounting for 80% of malignant CNS (central nervous system) tumors they are one of the most common primary brain tumors. Gliomagenesis is a multifactorial process involving an intricate interaction between a number of signalling cascades resulting in unrestricted proliferation and invasion. The invasive and proliferative nature of glioblastoma has been one of the impetuses for testing of new therapies to more expeditiously mitigate tumorigenic invasion, proliferation, and survival. Since glioma is a molecularly complex disease thus treatment failure with a single agent that targets one signalling abnormality may result from the uninhibited actions of other molecular abnormalities or from the need to target more than one oncogenic signalling cascade simultaneously.

Author(s): Henah Mehraj Balkhi, Taseen Gul, Syed Sana, Ehtishamul Haq

Abstract Full Text PDF