Archives of General Internal Medicine

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Commentary - Archives of General Internal Medicine (2023) Volume 7, Issue 3

Neuropathy: Nerve damage and its effects on daily life

Neuropathic pain is characterized by abnormal hypersensitivity to stimuli (hyperalgesia) and nociceptive responses to non-noxious stimuli (allodynia). The conditions and pathophysiological states that determine the development of neuropathic pain vary, including: B. Metabolic disorders, neurological disorders, and autoimmune diseases affecting the central nervous system "CNS" due to viral infections. Neuropathic pain has been estimated to have a prevalence of 3% to 17% in the general population. Most of the available therapies for neuropathic pain are moderately effective and have side effects that limit their use. Therefore, patients need other therapeutic approaches. This article reviews the current standard of care, emerging pharmacological approaches from completed Phase III clinical trials, and preclinical studies of promising new treatment options.

Author(s): Paola Fernandez

Abstract Full Text PDF

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