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Short Communication - Journal of Molecular Oncology Research (2022) Volume 6, Issue 2
Misusing autophagy-regulative nanomaterials for actuation of dendritic cells empowers fortified cancer immunotherapy
Dendritic cells (DCs), as the foremost capable antigen displaying cells, play a basic part in directing safe reaction and anti-tumor prepare. In any case, the immunosuppressive cells and variables dwelled within the tumor microenvironment (TME) posture different challenges that can demolish competent DC work comprising antigen introduction and resistant start. In this setting, creating powerful procedures to progress the work of DCs is basically required for progressing the viability of tumor immunotherapy. Autophagy is found to be closely related to the different capacities of DCs beneath physiological and neurotic conditions. Particularly, nanomaterials (NMs) can lock in within the clutter and consistency of autophagy to tweak their digestion system and work of DCs. Sensible plan of nanomaterials with autophagy control is of extraordinary importance to enact DCs and upgrade its immunological capacities, inciting vigorous and strong antitumor insusceptibility. In this survey, we think about the plan and optimization of nanomaterials with the work of controlling DCs autophagy, examine the most component of DCs autophagy initiated by nanomaterials and its application in tumor immunotherapy, advancing the advance and improvement of cancer immunotherapy procedures within the future.
Author(s): Behzad Baradn