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Rapid Communication - Journal of Molecular Oncology Research (2023) Volume 7, Issue 1
Inhibition of childhood cancer and evolution.
Cancer is the leading disease-related cause of death in children in developed countries. Arising in the context of actively growing tissues, childhood cancers are fundamentally diseases of deregulated development. Childhood cancers exhibit a lower overall mutational burden than adult cancers, and recent sequencing studies have revealed that the genomic events central to childhood oncogenes is include mutations resulting in broad epigenetic changes or translocations that result in fusion oncoproteins. Here, we will review the developmental origins of childhood cancers, epigenetic deregulation in tissue stem/precursor cells in numerous examples of childhood cancer oncogenes is and emerging therapeutic opportunities aimed at both cell-intrinsic and micro environmental targets together with new insights into the mechanisms underlying long-term squeal of childhood cancer therapy.
Author(s): Henrik Hansen