Research Article - Biomedical Research (2022) Volume 33, Issue 4

Identifying potential adverse effects in development and maintenance of masticatory system due to tooth loss.

Many investigations have been conducted previously on the association of different factors with low mastication ability. In the similar context, the current study aims to examine the adverse impact in developing and maintaining masticatory system in individuals with tooth loss. Pregnant female mice were included in the study and experiments were conducted on both the tooth extracted mice (experimental) and mice with intact teeth (control) on 30^th, 60^th, 90^th, 120^th, 180^th, and 360^th following their birth. There was no substantial difference in the mean body weights of the mice in both classes, according to the findings. Furthermore, in the test group of mice, there was no substantial difference in the number of named Me5 and TG neurons on the right and left sides. There was a substantial decrease in the number of labelled Me5 and TG neurons in the tooth extracted mice from the 60th to the 360^th postnatal day. On the 40^th day, there were no degenerative fibres on the intact side of the tooth extracted mouse, but normal degenerative changes were present in the axons and myelin sheaths on the tooth extracted side. The study concluded masticatory system’s development and maintenance involves sensory input from periodontal mechanoreceptive afferents.

Author(s): Mohammed Enamur Rashid, Khaleda Akhter

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