Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 504 6082390

Research Article - Biomedical Research (2017) Volume 28, Issue 11

Fetal anomalies detection in China by screening with ultrasound

Purpose: To correlate sonographic findings of fetal developmental abnormalities resulting from chromosomal aberrations and structural anomalies in 2nd trimester. Design: Cross-sectional study. Setting: Tertiary care centre.

Patients and Methods: Amid the reporting period from August 2007 to July 2014, prenatal fetal anomaly diagnosis in 9524 fetuses/babies were inspected and contrasted with post-natal diagnosis.

Results: Overall, 233 fetuses/babies had affirmed anomalies, prevalence 2.45%. Out of those fetuses/ babies, 22.31% (52/233) had chromosomal anomalies, prevalence 0.55%, and 78% (181/233) had ordinary chromosomes along with structural anomalies (major (43.64%; 79/181) and minor (56.35%; 102/181)), prevalence 1.9%. The affirmed anomalies distinguished prenatally were 102, giving a total sensitivity for prenatal fetal anomaly detection of 43.78% (102/233; 95% Confidence Interval (CI) 37.31-49.98), specificity of 99.95%, PPV of 95.33% and NPV of 98.61%. The aggregate detection rate prior to 22 gestation weeks was 40.34% (94/233; 95% CI 33.99-46.95). The pre-natal detection rate of chromosomal anomalies was 61.5% (32/52) and for structural anomalies, 38.7% (70/181).

Conclusion: In a routine clinical setting at a hospital, half of major structural anomalies in fetuses with normal chromosomes are identified by standard ultrasound exam in 2nd trimester. Chromosomal anomalies have the greatest probability for prenatal detection; the greater part is diagnosed by amniocentesis prior to standard ultrasound exam in high-risk women.

Author(s): Shuang Liu, Qingqing Wu, Zhaojuan Chen

Abstract Full Text PDF