Journal of Brain and Neurology

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Short Article - Journal of Brain and Neurology (2020) Volume 3, Issue 1

Evaluating the Anti-Hypoxic and Anti-Ischemice effects of some GABA-receptor mimetics in Brains of mice and rats

Cerebrovascular accident (CVA) in which cerebral hypoxia and ischemia happen is one of the most important causes of disability and mortality in adults, however, it is not treated properly yet. Since the main reason of neural death in this disease is the release of excitatory substances like glutamate, inhibition of neurons with GABA receptor mimetics may reverse the excitotoxicity. In this study, we investigated the anti-hypoxic and anti-ischemic effects of diazepam and phenobarbital (GABA-A allosterics) and baclofen (GABA-B agonist) in comparison to phenytoin (sodium channel blocker and positive control) and normal saline (negative control).

Author(s): Faezeh Nemati Karimooy

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