Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1-504-608-2390

- Biomedical Research (2009) Volume 20, Issue 1

Erythrocyte antioxidant enzymes and their correlation with malon-dialdehyde in malaria.

Invasion of human erythrocytes by malaria parasites causes alterations in antioxidant po-tential of the red cells. The present study was undertaken to investigate the erythrocyte an-tioxidant enzymes like superoxide dismutase(SOD), catalase(CAT) in malaria patients. Oxi-dative stress was estimated by measuring malondialdehyde(MDA) which is a marker for lipid peroxidation. 30 malaria patients were enrolled in this study. They were divided into 2 groups of 15 each with Plasmodium vivax malaria and Plasmodium falciparum malaria. Re-sults were compared with 20 healthy control subjects. Significant decrease(p<0.001) in SOD and CAT and increase in MDA (p<0.001) indicates that there is reduction in antioxidant en-zymes and increased vulnerability to free radical damage in erythrocytes. This study there-fore emphasizes the need for early treatment of malaria patients to reduce the red cell dam-age.

Author(s): Benedicta D?Souza, Vivian D?Souza, Swagata H, Vijayalaxmi K, Namratha A.S.

Abstract Full Text PDF

Get the App