Journal of Translational Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +441518081136

Research Article - Journal of Translational Research (2022) Volume 6, Issue 3

Effect of twelve meridian cordyceps correlated compounds on glycemic control in patients with type 2 diabetes mellitus: A before-after self-control study.

Aim: The present study aimed to evaluate the effect of Twelve Meridian Cordyceps Correlated Compounds (M12CCC), a new functional food, on glycemic control in patients with Type 2 Diabetes Mellitus (T2DM). Methods: The subjects recruited 30 patients with T2DM aged 30-75 years from Outpatients completing 90d trial. The 30 cases received M12CCC 4.5g/d for orally three times a day (1.5g/bag in 100 mL hot water before 30 min of each meal) for consecutive 90 d. Their base-line value including fasting plasma glucose (FPG), glycated hemoglobin (HbA1c) and oral glucose tolerance test 2-hour plasma glucose (OGTT2hPG) and these indexes value after intervention for 30 d,60 d and 90 d was measured. Results: Excluded the base-line value of HbA1c <6.5% cases because of blood glucose are controlled stably generally. The base-line value of HbA1c is more than 6.5% in 23 cases which compared with that value after treatment for 90 d showed that HbA1c declined 0.5% (P=0.001). FPG of treatment for 30 d, 60 d and 90 d differently compared with the base-line value indicated that there were no significant differences (P =0.603, P =0.233 and P=0.783). However, OGTT2hPG of treatment for 30 d, 60 d and 90 d was markedly decreased compared with the baseline value (P=0.000, P =0.000 and P=0.005) with no time-dependent manner. Body composition including body weight, BMI, TG, TC, UA, Muscle mass, fat mass, bone mass, body fat percentage, waist-hip ratio and visceral fat were no significant differences between baseline and 90 days. Conclusion: M12CCC has a strong regulating effect on decreasing HbA1c and OGTT2hPG to poor glycemic control patients.

Author(s): Jian Du1,2,3*, Yimeng Chen1,4, Zhiyun Cao1,2,3, Xiaoting Yang1, Xiaofang Wu2, Yang Yan2, Ruichen Chen5

Abstract Full Text PDF

Get the App