Opinion Article - Journal of Clinical Oncology and Cancer Research (2022) Volume 5, Issue 2
Diagnosis and different types of treatment and management of osteosarcoma, ewing sarcoma, chondrosarcoma.
Osteosarcoma, Ewing sarcoma, and chondrosarcoma are three forms of bone malignancies. Despite the fact that these diseases account for less than 1% of all cancers diagnosed each year, their morbidity and mortality are significant. Osteosarcoma is considered to develop when malignant primitive mesenchymal cells transition into osteoblasts, which then produce a malignant osteoid matrix. Osteosarcomas can develop in any bone, but they're most commonly found in the metaphyses of long bones. The distal femur, proximal tibia, and proximal humerus account for about 60% of all cases. 3 The growth plate, which is responsible for active bone production and elongation, is found in the metaphysis of a bone. As a result, osteosarcomas tend to develop at the age and site when bone growth is most vigorous and cells are most susceptible to alterations. Osteosarcomas can spread throughout the body. By spreading intraosseously within the same bone or transarticularly across a joint, such as the tibia and femur, primary cancers can develop "skip lesions." The lungs are the most common site of systemic osteosarcoma metastases. The second most common place for metastases is the bones of another extremity.Author(s): Arvind Rajwanshi