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Commentary - Journal of Clinical Nephrology and Therapeutics (2021) Volume 5, Issue 6
Complications of erythropoietin in navigated brain gene therapy
Erythropoietin is thought because the requisite protein for red corpuscle production. Its receptor, expressed at a high level on blood corpuscle precursor cells, is additionally found on epithelium, neural and alternative cell varieties. Glycoprotein and glycoprotein receptor expression within the developing and adult brain counsel their doable involvement in neurodevelopment and neuroprotection. Throughout anemia stress, glycoprotein, that is drive inducible, will contribute to brain equilibrium by increasing red corpuscle production to extend the blood element carrying capability, stimulate gas production to modulate blood flow and contribute to the neurovascular response, or act directly on neural cells to produce neuroprotection as incontestable in culture and animal models. Clinical studies of glycoprotein treatment in stroke and alternative diseases offer insight on safety and potential adverse effects and underscore the potential pleiotropic activity of glycoprotein. Herein, we tend to summarize the roles of EPO and its receptor within the developing and adult brain throughout health and malady, providing initial a quick summary of the well-established EPO biology and sign, its hypoxic regulation, and role in organic process.
Author(s): Mohammad Nabavi