Biomedical Research

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- Biomedical Research (2013) Volume 24, Issue 2

Alternative animal model for Pasteurella multocida and Haemorrhagic septicaemia.

A suitable animal model is essential in understanding a condition caused by microorganisms. In this study in order to study the changes in haemorrahgic septicaemia caused by Pasteurella multocida serotype B, Sprague-Dawley (SK/WDY) rats were immuosuppressed with dexamethasone and challenged with P.multocida serotype B:2. The animals were monitored/inspected twice daily. Any changes in behaviour, movement, eating and development of any signs and symptoms were recorded. Immune-suppressed rats showed signs of haemorrahge and lesion in the lungs.

Author(s): Jamal Hussaini, Nazmul MHM, N Masyitah, Mahmood A. Abdullah and Salmah Ismail

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