This study was conducted at Department of Zoology, University of Gujrat, Pakistan during 2016- 2017 as a term paper for Master of Philosophy. The data regarding water pollution and human health was obtained and compiled through a thorough review of various published research articles of international reputed journal and relevant books. Water covers about 70% Earth’s surface. Safe drinking water is a basic need for all humans. The WHO reports that 80% diseases are waterborne. Industrialization, discharge of domestic waste, radioactive waste, population growth, excessive use of pesticides, fertilizers and leakage from water tanks are major sources of water pollution. These wastes have negative effects on human health. Different chemicals have different affects depending on their locations and kinds. Bacterial, viral and parasitic diseases like typhoid, cholera, encephalitis, poliomyelitis, hepatitis, skin infection and gastrointestinal are spreading through polluted water. It is recommended to examine the water quality on regular basis to avoid its destructive effects on human health. Domestic and agriculture waste should not be disposed of without treating.