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Photodynamic Therapy for Patients with Basal Cell Carcinoma: N.N. Alexandrov National Cancer Center Experience

Background: In this study we present the retrospective analysis of photodynamic therapy with photosensitizer Photolon using the data obtained from 130 patients with basal cell carcinoma (T1N0M0, I stage).

Methods and findings: The treatment was easily tolerated by the patients and high therapeutic and cosmetic effects were obtained after Photolon injection of 2-2.5 mg/kg and subsequent irradiation by the laser with wavelength 660 nm in light doses 50-200 J/cm2. Complete regression of primary and recurrence carcinomas was observed in 90.9% and 88.9%, respectively. In terms of the observation of 3 to 76 months of local tumor recurrence was detected in 7.7% of cases (n=10).

Conclusion: Photodynamic therapy of basal cell carcinoma with Photolon can be recommended when there are complications with traditional treatment of the disease.

Author(s): Tzerkovsky DA