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Forced Expiratory Volume Factors of Stage III Non-Small Cell Lung Cancer Patients.

Objectives: Forced expiratory volume in 1 (FEV1) second is known as the amount of air volume that can forcibly be blown out in one second, after full inspiration. Average FEV1 values between 80% and 120% are considered as normal. The determinants of FEV1 are aimed to identify in the report for stage III non-small cell lung cancer (SIIINSCLC) patients.

Background: Previous research articles have reported that the average FEV1 values in healthy individuals depend on height, age, body mass index, sex and ethnicity. Little studies have been performed regarding the FEV1 determinants for SIIINSCLC patients.

Materials and Methods: Published records on 239 SIIINSCLC patients with 23 study characters (variables/factors) are considered in the present study. The study variable FEV1 is positive and heterogeneous. Statistical analysis technique namely, joint generalized linear Log-normal models is used for analyzing the response FEV1.

Results: The mean FEV1 (MFEV1) is higher for SIIINSCLC patients who are current smoker (P=0.0601), or who have lower body mass index (BMI) (P=0.0599). Location of tumor is positively partially related (P=0.2365) with the MFEV1. The MFEV1 is higher for SIIINSCLC patients with histology level at squamous cell carcinoma (P=0.1088), or T-stage at level (T2=2) (P=0.1752), or N-stage at level (N2=3) (P=0.1440) and (N4 or Nx=4) (P=0.0142) than the other levels. The MFEV1 is higher for SIIINSCLC patients with chemotherapy at levels (standard sequential=3) (P<0.0001) and (standard concurrent=4) (P<0.0001), than the patients with no chemo level. The FEV1 variance (FEV1V) is higher for SIIINSCLC patients at older ages (P=0.1282), or never/exsmoker patients (P=0.2985). The FEV1V increases as the number of positive lymph node stations increases (P=0.0017). The FEV1V is inversely related with T-stage at level (T2=2) (P=0.0172) and at level (T4 or Tx=4) (P=0.0240). The FEV1V decreases at the higher equivalent dose (P=0.1822), or at larger gross tumor volume (P=0.0003), or at higher survival times (P=0.0451).

Conclusions: The FEV1 determinants for both the mean and variance have been identified for SIIINSCLC patients. These results may help the lung cancer specialists. The current findings of FEV1 (related to SIIINSCLC patients) are new addition to the lung cancer literature.

Author(s): Rabindra Nath Das