Invertebrate animals exhibited successful detoxification and storage of hazardous inorganic contaminants. Moreover, waterflea Daphnia sp., other crustacean arthropods and molluscan species were implied as sentinel organisms for aquatic contaminants. Benthic invertebrates might be used as biological monitors for heavy metal pollution. They spend most of their lives at the contaminated site. They can determine the concentration of existed heavy metal pollution. A variation in the efficiency of heavy metal accumulation was shown between different invertebrate groups. Molluscan animals specially gastropods showed the greatest capability to bioaccumulate heavy metals within their digestive cells. They acquired higher bioaccumulation factor relative to arthropods and annelids. At the cellular level, heavy metals might be stored after detoxification as granules of different shapes and sizes or as lipid droplets. The present review discusses the capability of different invertebrate groups to detoxify and store inorganic contaminants and their efficiency as possible biomonitor organisms for aquatic ecosystem.