Vaginal malignant melanoma is a rare and aggressive neoplasm of the genital tract. It is associated with early dissemination and metastasis. It presents a diagnostic dilemma as it is often confused with squamous cell carcinoma of the vagina and/or cervix, hence, resulting in late diagnosis and poor prognosis. We present a case of malignant melanoma of vagina which was extensively metastatic at diagnosis. It was initially diagnosed after a frontal craniotomy done for a space-occupying lesion in the brain. Subsequently, multiple nodes were detected in axillary and inguinal regions. She was treated with palliative whole brain radiotherapy. Then, she received 6 cycles of adjuvant chemotherapy, paclitaxel and carboplatin. Her disease progression is stable and her KPS has improved with the treatment. Prompt detection of metastasis followed by adjuvant chemotherapy, radiotherapy and immunotherapy can control disease progression in metastatic disease.