Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article - Biomedical Research (2017) Volume 28, Issue 19

A study on the antibacterial effect of Acanthopanax sessiliflorum on inflammatory diseases in the oral cavity

This study was conducted to investigate the antimicrobial effect of Acanthopanax sessiliflorum extract, a natural medicinal substance against Candida albicans (C. albicans), a common inflammatory disease in the oral cavity, and to utilize it in the prevention and treatment of inflammatory oral diseases. In studying the antimicrobial effect of 80% ethanol Acanthopanax sessiliflorum extract against C. albicans, disc diffusion method (paper disk) was used, while growth curve, minimum inhibitory concentration and minimum bactericidal concentration, and colony-forming unit were measured. As a parameter of the antimicrobial effect of Acanthopanax sessiliflorum extract, the clear zone of C. albicans was found to be 15 mm at 40 mg/ml, 14 mm at 45 mg/ml, 19 mm at 50 mg/ml, 20 mm at 55 mg/ml and 21 mm at 60 mg/ml, respectively. The minimal inhibitory concentration (MIC) of the extract against C. albicans was 20 mg/ml, and minimum bactericidal concentration (MBC), which is the concentration where bacteria do not exist, was found to be 50 mg/ml. As for the colony-forming unit (CFU), there was bactericidal effect at 20 mg/ml, while no bacteria were observed at 50 mg/ml. Thus, the antimicrobial effect against C. albicans was enhanced as the concentration of Acanthopanax sessiliflorum extract increased. Based on these results, Acanthopanax sessiliflorum extract can be considered as a suitable replacement for antimicrobial agents. Therefore, developing oral health care products, such as gargles or toothpastes using natural Acanthopanax sessiliflorum extract, would be beneficial in preventing inflammatory oral disease.

Author(s): Young-Soon Choi, Na-Hyun Kim, Hyo-Jin Kim, Su-Jin An, Bit-Na Lee, Min-Ju Jung, Ji-Young Hwang, Seoul-Hee Nam

Abstract Full Text PDF