Journal of Genetics and Molecular Biology

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Journal of Genetics and Molecular Biology 44 7897 074717

MICRO RNA PROFILING JOURNALS

MicroRNAs (miRNAs) are small RNAs which expresses many genes.. MiRNA expression profiling is gaining popularity because miRNAs, as key regulators in organic phenomenon networks, can influence many biological processes and have also shown promise as biomarkers for disease. Technological advances have enabled the event of varied platforms for miRNA profiling, and an understanding of the strengths and pitfalls of various approaches can aid within the effective use of miRNA profiling for diverse applications. We review here the main considerations for completing and interpreting results of miRNA profiling studies, also as current and emerging applications of miRNA profiling.
MicroRNA expression profiling has proven to be useful for identifying miRNAs that are important in regulation of a variety of processes, including organismal development and establishment and maintenance of tissue differentiation. As a result, miRNA expression biomarkers are finding application in diagnosis of tissue differentiation state in cancers of unknown origin, and miRNAs are being investigated as reagents for re-programming of cell fate in somatic cell applications. For investigators studying mechanisms of gene regulation, measuring miRNA expression can inform systems-level models of gene regulation, especially when miRNA information is combined with mRNA profiling and other genome-scale data. Finally, miRNAs are shown to be far more stable than mRNAs during a range of specimen types – including blood plasma/serum, urine and formalin-fixed issue blocks – and also are measurable with much greater sensitivity than proteins (due to the very fact that they will be amplified by RT-PCR).

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