Journal of Neurology and Neurorehabilitation Research

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Journal of Neurology and Neurorehabilitation Research 44 7897 074717

Membranous Nephropathy

Membranous nephropathy  is a unique glomerular lesion that is the most common cause of idiopathic nephrotic syndrome in no diabetic white adults. About 80% of cases are renal imperfect and 20% are associated with other general diseases or exposures. This journal focuses only on PMN. Most cases of PMN have an mixing IgG4 auto antibody to the podocyte membrane antigen PLA2R (70%), biopsy evidence PLA2R stain indicating recent immunologic disease and activity despite negative serum antibody levels (15%). The remaining 10% short of obvious anti-PLA2R/THSd7A antibody or antigen likely have an PMN perhaps secondary to a different, still unidentified and anti-podocyte antibody. Significant clinical and experimental data was suggests these antibodies are pathogenic. Clinically, 80% of  the patients with PMN present with nephrotic syndrome and 20% with non nephrotic proteinuria. Whole, about one third undergo spontaneous remission, particularly those with absent or low anti-PLA2R levels, one-third progress to ESRD over 10 years, and the remainder develop nonprogressive CKD.

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