Allied Journal of Medical Research

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Allied Journal of Medical Research 44 7897 074717

Insulin Alpha-beta Peptide-6

Insulin resistance, hyper-insulinemia and products associated to insulin metabolism can affect the amyloid cascade and promote the onset of Alzheimer`s disease or aggravate the condition, in early or adulthood no matter the event of type 2 diabetes. The changes described in pathological studies and molecular research, classify two sorts of mechanism involved cognitive impairment in these cases: one associated with cerebrovascular events due the action of vascular risk factors, and therefore the other more controversial, non-cerebrovascular mechanism involving the interaction of insulin with Aβ within the entorhinal cortex and hippocampus, also as its synaptogenesis action that involves signalling of intracellular molecular paths within the modulating of neurotransmitters like acetylcholine, norepinephrine and glutamate receptors. supported a literature review, the role of insulin within the Central nervous system is examined alongside its participation within the amyloid genesis process in progression to Alzheimer Disease. the highest journals are peer reviewed scholarly journals.

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