Microbiology: Current Research

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Microbiology: Current Research 44 7897 074717

Glycomics Impact Factor

Cells run on carbohydrates. Glycans, sequences of carbohydrates conjugated to proteins and lipids, are arguably the foremost abundant and structurally diverse class of molecules in nature. Recent advances in glycomics reveal the scope and scale of their functional roles and their impact on human disease.

Glyconjugates provide dynamic structural diversity to proteins and lipids that's aware of cellular phenotype, metabolic state and to the developmental stage of cells. Complex glycans play critical roles in intercellular and intracellular processes, which are fundamentally important to the event of multicellularity . Unlike nucleic acids and proteins, glycan structures aren't hardwired into the genome, depending upon a template for his or her synthesis. Rather the glycan structures that find yourself on a polypeptide or lipid result from the concerted actions of highly-specific glycosyltransferases , which in-turn are dependent upon the concentrations and localization of high-energy nucleotide sugar donors, like UDP-N-acetylglucosamine, the endpoint of the hexosamine biosynthetic pathway. Therefore, the glycoforms of a glycoprotein depend on many factors directly tied to both organic phenomenon and cellular metabolism.

High Impact List of Articles
Conference Proceedings

Relevant Topics in Immunology & Microbiology

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