Journal of Genetics and Molecular Biology

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Journal of Genetics and Molecular Biology 44 7897 074717

Gene Silencing Scholarly Peer-review Journal:

Gene silencing is the regulation for the gene expression in a cell to prevent the expression of an certain gene. Polycomb Group (PcG) proteins can form the memory of transient transcriptional repression that is necessary for the development. In Drosophila, DNA elements can be termed as Polycomb Response Elements (PREs) recruit PcG proteins. How PcG activities are targeted to PREs to maintain the repressed states only in the appropriate developmental contexts has been difficult to elucidate. PcG complexes can also modify chromatin, but can also interact with both RNA and DNA, and RNA is implicated in PcG targeting and function. Gene silencing can also consider a gene knockdown mechanism since the methods used to silence genes, such as RNAi, CRISPR, or siRNA, generally reduce the expression of a gene by at least 70% but do not completely to eliminate it.

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