Journal of Histology and Cell Biology

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D-cell Hypothesis

Another hypothesis, â€D-cell hypothesisâ, for clarifying mesolimbic DA hyperactivity in pathogenesis of schizophrenia is appeared in Figure 1. In minds of patients with schizophrenia, brokenness of neural undifferentiated cells in the subventricular zone of horizontal ventricle causes the abatement of D-neurons in the striatum and core accumbens [8,34]. This prompts the diminishing of the measures of follow amines in the cores, however direct confirmations have not yet been illustrated. Development of the sidelong ventricle, a typical finding reported in mind imaging investigations of schizophrenia, is perhaps because of brokenness of neural undifferentiated organisms of the subventricular zone.

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