Journal of Pharmacology and Therapeutic Research

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The miniaturized Near-Infrared Spectroscopy (NIRS) enables convenient, non-destructive and real-time testing of medicines that are circulating on the sector or throughout the availability chain. we've successfully been ready to detect falsified Viagra employing a new low-cost, consumer-type NIRS. In like manner, we've distinguished the first Viagra from its generic versions with an equivalent dose. this is often a promising way of ensuring medicines authenticity by watching their chemical ‘fingerprints’. Portable screening technologies for medicine quality assurance on the sector or throughout the availability chain are currently growing and complementing the present approach for combating the falsified products, i.e., safety features on the packaging and laboratory analysis of suspect samples. In total, 78 spectra of Sildenafil-based tablets were recorded and classified using the K-Nearest Neighbors algorithm that relies on the Euclidean distances between measured values. Accuracy of our model was assessed using cross validation and bootstrapping techniques. In result, the miniaturized NIRS correctly ordered all tablets consistent with their manufacturer and indicated the falsified tablets, which spectra not only differed in shape from the authentic versions, but also show high spread in chemo-physical characteristics, which suggest poor manufacturing practices of the falsified products.

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