+441518081136Tumor infiltrating lymphocytes and tertiary lymphoid structure as prognostic and predictive factor for neoadjuvant chemotherapy in stage ii & iii breast cancer
International Conference on Oncology & Cancer Therapy
March 18-19, 2019 | London, UK
Mohamed L
Tanta University, Egypt
Posters & Accepted Abstracts : J Med Oncl Ther
Abstract:
Introduction: Tumor-infiltrating lymphocytes (TILs) have a
strong prognostic and predictive value in triple-negative breast
cancer (TNBC) and HER2 enriched subtype but no other breast
subtypes but no studies have evaluated tertiary lymphoid
structure (TLS).
Materials and Methods: Eighty patients with stage II and III
breast cancer in Tanta oncology and pathology departments
with luminal A, B and her 2 enriched and TNBC diagnosed with
core needle biopsy treated with neoadjuvant chemotherapy (4
AC followed by 12-week paclitaxel + herceptin). TIL and TLS were
evaluated histopathologically using hematoxylin and eosin–
stained slides. The immune cell aggregates which were TLS
positive showed the presence of CD20+B lymphocytes within
the follicles, with areas of CD3+, CD4+ T lymphocytes mainly
in the periphery [T-cell zone] resembling the highly organized
structures of secondary lymphoid organs.
Results: TLS were detected in 53.7% of the tumors in whole
breast groups, 83.7% in triple negative subgroup. Increased
number of tumor infiltrating lymphocytes and tertiary lymphoid
structure are associated with longer OS and DFS for TNBC and
HER2-positive breast cancer.
Biography:
E-mail:
lamissmohamed2@yahoo.comPDF HTML