TISSUE ENGINEERED POLY (VINYL ALCOHOL) MESH FOR THE TREATMENT OF ABDOMINAL HERNIA
Joint Event on World Congress on BIOCHEMISTRY AND ENZYMOLOGY & 2nd Global Conference on TISSUE ENGINEERING AND REGENERATIVE MEDICINE, STEM CELL RESEARCH
March 25-26, 2019 | Amsterdam, Netherlands
Daniella Feher and Kristof Molnar
Semmelweis University, Hungary
Posters & Accepted Abstracts : J Genet Mol Biol
Hernia is the weakness or defect in the abdominal wall or inguinal area. One of the solutions can be the usage
of surgical mesh. To fend off the effects of intraperitoneal positioned non-degradable mesh our research
group created absorbable scaffolds by electrospinning. For the biocompatibility experiments In vitro studies
were performed on Human lung epithelial (A549) cell line and the In vivo evaluations were observed on Wistar
rats (n=45, 200-250g). In this animal model to determine the biological behavior abdominal wall defect was
performed than was covered with the nanofiber mesh. Adhesion formations were measured by a modified Diamond
score. From the samples macroscopically and histological responses were graded. In vitro examination
showed that the monomers of the nanofiber are biocompatible for the cells. According to the histological examinations
all samples were integrated to the surrounding tissue and there were no foreign body reaction. Significantly
more adhesion formation were found on the non-absorbable suture line (n=19) than were attached to
the surface of the mesh.
The biocompatibility of the nanofiber surgical mesh was demonstrated by our studies. This nanofiber mesh could be a promising scaffold for the tissue engineering.
Daniella Feher is a PhD student from Semmelweis University, Hungary. Her research is about regenerative medicine tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating cells, tissues and nanofibers to restore and establish normal function.