+44-1518-081136The efficiency of intracerebral and intravenous MSCs administration in resolving diffused and neuritic Amyloid-β aggregates by recruiting bone marrow-induced Microglia M2 type in Alzheimer’s disease rat model
Joint Event on International Conference on Palliative Care, Obstetrics and Gynecology & International Conference on Stroke and Clinical Trials
February 28-March 01, 2019 | Paris, France
Mai M Anwar, Badawi A M, Nadia A Eltablawy, Ola S M Al and Laila Ahmed R
National Organization for Drug Control and Research, Egypt Al-Azhar University, Egypt Cairo University, Egypt
Posters & Accepted Abstracts : Res Rep Gynaecol Obstet
Abstract:
Background & Aim: Memory and learning disorders have
been characterized by being a devastating long-term
incurable diseases with a huge social and economic impact
on worldwide society in addition to a diminished efficient
available medical treatments with the potential for restoring
and modifying memory defects onset and drawbacks.
Deep brain stimulation via using neuroprotective inducers
for restoring destructive degenerative brain structural
diseases such as AD can be considered as being a promising
successful therapy due to its various targets and underlying
mechanisms for improving brain dysfunction by increasing
synaptic plasticity and transmission. The main aim of this
study is to suggest therapeutic medical protocol with a
neuro regenerative potentials having the ability to restore
normal brain mechanisms and mental functions in addition
to understanding triggering pathways via which normal
neurons diverse population restoration process can occur.
Method: Rats were divided randomly into nine groups,
(G1) control group (G2) rats received lipopolysaccharide
(LPS) injection (G3) LPS induced rats received NaHS, (G4)
LPS induced rats received MSCs intracerebrally, (G5) LPS
induced rats received MSCs+NaHS, (G6) LPS induced rats
received kefir+Ginko Biloba (GB), (G7) LPS induced rats
received MSCs+kefir+GB, (G8) LPS induced rats received
NaHS+kefir+GB and (G9) LPS induced rats received
MSCs+NaHS+kefir+GB.
Result: AD induction by LPS in rats resulted in downregulation
of CBS and GSH brain tissue level accompanied with
overexpression in amyloid ò, MAPK, Tau, ACAT and MDA
brain level in addition to elevated caspase-3 serum activity
level.
ConclusionThe administration of suggested medical
protocol composed of MSCs and/or NaHS and/or kefir+GB
resulted in relieving AD pathological deposited hallmarks
with restoring the normal inflammatory brain excitatory
levels by functioning as a potent neuro regenerative with the
advantage of being easily implemented on human subjects
as a result of its safety but with more clinical care obligations
during conducting experimental design to minimize
unpredictable drawbacks.
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