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THE EFFICACY OF TOCOTRIENOLS IN THE TREATMENT OF NONALCOHOLIC STEATOHEPATITIS: A SYSTEMATIC REVIEW
Joint Event on International Conference on SURGERY AND ANESTHESIA & 3rd International Conference on GASTROENTEROLOGY
November 12 -13 , 2018 | Rome , Italy
Higinio T Mappala
Jose Reyes Mem. Medical Centre Manila, Philippines
Posters & Accepted Abstracts : Case Rep Surg Invasive Proced
Abstract:
Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease which may progress to non-alcoholic steatohepatitis (NASH). Currently there are no therapeutic strategies for such disease. Only lifestyle modification through diet and exercise were proven to afford some benefit in patients with NAFLD. No pharmacologic agents have so far been approved for the treatment of NAFLD or NASH. Therefore, most clinical efforts have been directed at treating the components of metabolic syndrome, namely obesity, diabetes, hypertension and dyslipidemias. Other interventions are directed at specific pathways potentially involved in the pathogenesis of NAFLD, such as insulin resistance, oxidative stress, pro-inflammatory cytokines, apoptosis, bacterial overgrowth, and angiotensin pathway. Objective: This lecture aims to show the potential of tocotrienols as a promising therapeutic option for NAFLD. Method: This is a systematic review of randomized controlled trials on the effects of Tocotrienols on non-alcoholic fatty liver disease. (NAFLD) Conclusion: Tocotrienols may yet prove to be an effective treatment for non-alcoholic fatty liver disease.
Biography:
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