Biomedical Research

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THE CHALLENGES IN MANAGING HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF)

Joint Event on 2nd World Congress on CARDIOLOGY & 39th Annual Congress on MICROBIOLOGY AND MICROBIAL INFECTION
July 23-24, 2018 | Rome , Italy

Samer Ellahham

Cleveland Clinic, USA

Posters & Accepted Abstracts : Biomed Res

DOI: 10.4066/biomedicalresearch-C1-003

Abstract:

The learning objectives of the current study is to demonstrate the association between heart failure with preserved ejection fraction (HFpEF) and survival, given a patient with heart failure (HF), recognize HFpEF based on clinical signs and symptoms, physical examination, echocardiography, and radiographic findings, classify patients at high risk of hospitalization and mortality through assessing risk factors, clinical presentation, and interpretation of biomarkers, distinguish the clinical presentation, diagnosis, and treatment strategies of HFpEF from those of HF with reduced ejection fraction, given a patient with HFpEF, develop an individualized treatment plan based on current evidence and assess the potential role of future pharmacotherapies for HFpEF. Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF) and, as life expectancies continue to increase in western societies, the prevalence of HFpEF will continue to grow. In contrast to heart failure with reduced ejection fraction (HFrEF), no treatment has been proven in pivotal clinical trials to be effective for HFpEF, largely because of the pathophysiological heterogeneity that exists within the broad spectrum of HFpEF. This syndrome was historically considered to be caused exclusively by left ventricular diastolic dysfunction, but research has identified several other contributory factors, including limitations in left ventricular systolic reserve, systemic and pulmonary vascular function, nitric oxide bioavailability, chronotropic reserve, right heart function, autonomic tone, left atrial function and peripheral impairments. Multiple individual mechanisms frequently coexist within the same patient to cause symptomatic heart failure, but between patients with HFpEF the extent to which each component is operative can differ widely, confounding treatment approaches. This lecture focuses on our current understanding of the pathophysiological mechanisms underlying HFpEF, and how they might be mechanistically related to typical risk factors for HFpEF, including ageing, obesity and hypertension.

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