Journal of Medical Oncology and Therapeutics

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Synthesis of metallacarboranes-based delocalized lipophilic cations for diagnostics and Cancer treatment

12th World Cancer Congress
July 23-25, 2018 | Moscow, Russia

Dugin Sergey, P Belov, E Gurkova, V Pasko and P Storozhenko

JSC RSC GNIIChTEOS, Russian Federation

Posters & Accepted Abstracts : J Med Oncl Ther

Abstract:

Metallacarboranes represent the wide class of polyhedral boron compounds with low toxicity, high boron content and catabolic stability. Applied in boron neutron capture therapy metalcarboranes derivatives are of interest. All of that sets apart metallacarboranes in the separate broad group of perspective pharmacophores. Carboranes containing the Delocalized Lipophilic Cations (DLCs) arouse big interest. DLCs are perspective compounds for diagnostics and cancer treatment. Eight compounds based on fluorescent dyes Rodamine 6G, B, were synthetized and characterized in our laboratory. Developing this direction, the optimal methods of bis (dicarbollide) cobalt-based DLCs syntheses were invented.

Biography:

Dugin Sergey has completed his PhD at the age of 25 years from RSC GNIIChTEOS, Russian Federation. He is the leading scientist in GNIIChTEOS. He has over 200 publications that have been cited over 200 times, and his publication H-index is 20 and has been serving as an editorial board member of reputed Journals.

E-mail: [email protected]

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