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Randomized, blinded, split-face trial to assess the brightening efficacy of liquid crystal retinol serum in two different concentrations, both in application treatment and with sonophoresis
Joint Event on 2nd Global Summit on Dermatology and Cosmetology & 3rd International Conference on Wound Care, Tissue Repair and Regenerative Medicine
September 09-10, 2019 | Edinburgh, Scotland
Malwina Zasada
Medical University of Lodz, Poland
Posters & Accepted Abstracts : Dermatol Res Skin Care
Abstract:
Background: Retinol modulate the amount of melanin
in the epidermis by directly acting on melanocytes and
epidermal keratinocytes. Topical application of retinol
reduces the transport of melanosomes, which leads to rapid
loss of melanin through the skin. An appropriately designed
cosmetic product with retinol and regimen of treatment can
improve facial hyperpigmentation appearance with improved
tolerability.
Objective: We sought to evaluate the brightening efficacy and
tolerability using a 0.3% and 0.5% novel, liquid crystal formula
of retinol.
Methods: The formula of serums were applied once a day to
the face for a period of 12 weeks, N=37. The treatment with
sonophoresis were carried out once per week for 7 weeks,
N=16. Evaluation were conducted at days D(0) baseline and
after the treatment, D(84) and D(49), respectively. Multi
Probe Adapter (MPA) system and Fotomedicus imaging
system was used to assess the efficacy of treatments. The
VAS method enabled the results to be determined by three
independent specialists. The study was approved by the
Bioetic Commission No. RNN / 281/16 / KE 2017 and No. KE
/ 229/19.
Results: Skin hyperpigmentation and uneveness of color
of skin surface gradually decreased over the treatments,
both left and right part of the face. In VAS assessment skin
discoloration was reduced. Mild side effects appeared in
several cases, mainly after the first sonophoresis treatment
with 0.5% retinol and was more intense on the left part
(0.5%) during the whole application treatment. There were
no significance changes between left and right side of the face
(p<0.05).
Conclusions: Regular use of retinol both in application
and with sonophoresis results in brightening of the skin.
However, less hypersensitivity and lower intensity of side
events occurred on the right (0.3%) in the treatment with
sonophoresis. Moreover, the concentration of the retinol
does not significantly affect brightening of the skin. It could
suggest that formulas based on lower concentrations of
retinol might be used to offer comparable activity while
reducing the chance of side effect reactions.
Biography:
Malwina Zasada is a PhD student at Medical University of Lodz. She is the first author of original works in the field of cosmetic dermatology. She presents the results of her research at national and international conferences. She is a reviewer of scientific papers in cosmetics and dermatological journals. Within her scientific interests are cosmetic formulation and application therapy with active ingredients, i.e. niacinamide, vitamin C and retinol. She is the author of her own cosmetic product, which she has subjected to many tests, both in vivo and in vitro.
E-mail: malwina.zasada@gmail.com
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