Prostate Cancer new approaches and treatments from the quality of life perspective
14th International Conference on Cancer and Cancer Therapy
December 05-06, 2019 | Dubai, UAE
A A Medical Center Dubai, UAE
Scientific Tracks Abstracts : J Med Oncl Ther
Aim: Over the last 5 years the understanding of prostate cancer
behavior, improvement in technologies relating to diagnostic
techniques, better surgical and radiotherapy methods and
new emerging drugs have pushed us to changing our insight
to prostate cancer. The aim in this talk is to give an overview
of new clinical applications and techniques that improve lifespan
as well as the quality of life in both the patients and their
Method: The presentation is based on relevant scientific data available relating to changes that occurred over the last few years in diagnosis, treatment and follow-up of prostate cancer patients.
Findings: When and how to screen prostate cancer patients has been a major concern among communities, health care providers and the related medical societies’ guidelines. Strategies resulting in overdiagnosis versus un-detection of malignant tumors are based on the fact that prostate cancer may not be actually one type of disease but a large spectrum. Use of imaging has evolved our thinking of screening. Multiparametric Prostate MRI has given us 2 unique leverage: (i) we can detect if the PSA elevation is more predictive of cancer or other pathologies of the prostate gland Pi- RADS Scoring System (ii) we can do more accurate biopsies to identify cancer coupling MRI images with transrectal ultrasound images during biopsy in fusion biopsy systems. Biomarker studies to improve PSA sensitivity and specifity is still a work-in-progress. Avoiding unnecessary biopsies and having an imagery follow-up of suspicious or cancerous cells increase the quality of life. It is safer for patients to undergo ‘active surveillance’with new advances. Once at a treatment phase, robotic surgery is of course the gold standard to improve patients recovery time, time to catheter removal and post-surgery erection quality and recovery. Previous guidelines dictated that patients with tumors limited to the capsule can only have definitive treatments. New data show that even in patients with positive lymph node limited to iliac nodes and T3 patients with no fixation to the rectum are candidates for surgical tumor removal. Decreasing the tumor burden with a minimally invasive surgery has been proven to increase survival. Additional excelling of radiotherapy techniques also increased in patients with high stage surgeries as well as those who are not candidates for surgical procedures. Local radiotherapy results are as promising as surgeries. High intensity focused ultrasound, cryotherapy options are also present for patients. Medical therapies have also improved to include new hormonal approaches, immune therapies and more targeted anti-neoplastic medical therapies. While improving treatment results, many of the new regimens are also aiming at preventing or decreasing many cardiac, bonerelated and sexual dysfunctions. Recovery protocols for erectile dysfunction are also more effective. Adjunctive therapies such as low-intensity shockwave therapies, PRP to oral therapies are expected to give better recovery in a shorter period of time. For scientific proof of adjunct therapies we need to wait for longterm results to appear.
Conclusion: Being one of the major cancers in male, prostate cancer diagnosis, treatments and follow-up protocols have been changing rapidly over the last few years. Due to better diagnostic tools, better surgical technologies and better innovations in both pharmacotherapy, medical device and radiotherapy options provide prolonged survival, better survival-free follow-up and improved quality of life.
Haluk Kulaksizoglu is an experienced Professor of Urology with a demonstrated history of working in the hospital & health care industry. He is skilled in Prostate Diseases, Andrology, Urodynamic, Medical Devices, Kidney Stones, and Kidney Cancer. Strong healthcare services professional with a doctorate focused in medicine from Cerrahpasa Medical School.
E-mail: [email protected]