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Prospecting, development, optimization and clinical trial of new heterologous fibrin sealant derived from snake venom: From bench to the bedside

Joint Event on 2nd International Conference on Tissue Science and Molecular Biology, Stem Cells & Separation Techniques
June 06-07, 2019 | London, UK

Rui Seabra Ferreira Jr

Universidade Estadual Paulista (UNESP), Brazil

Posters & Accepted Abstracts : Biomed Res


To bridge the GAP between basic and applied sciences is needed to push forward disease research and therapeutics. What types of drug leads are truly“druggable”, sit in “patented bioproducts space” and can be pushed towards clinical trials? We present one successful translational case of bioproduct from laboratory bench to the bedside. Although animal toxins present excellent candidate molecules because they have high specificity for a cellular receptor without side effects, few drugs are approved for human use. Considering that infectious diseases could be transmitted via human blood a new heterologous fibrin sealant (HFS) is proposed, whose components are a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich cryoprecipitate extracted from the blood of Bubalus bubalis buffaloes. This new bioproduct has been used as a coagulant, sealant, adhesive and recently as a scaffold candidate to bone and cartilage repair using mesenchymal stem cells. Thus, we show its pre-clinical applications aiming at repairing nervous system traumas and bone regeneration. Also, we have finished an innovative safety trial phase I/II to treat chronic venous ulcers concluding that the product is safe and clinically promising candidate for this purpose due its preliminary effectiveness.



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