Materials Science and Nanotechnology

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Polymer - Lipid hybrid nanovehicles designed for synergistic drug delivery for solid tumor management

2nd International Conference on Materials Science and Materials Chemistry
March 20-21, 2019 | London, UK

Madhu Gupta

Delhi Pharmaceutical Science and Research University, India

Posters & Accepted Abstracts : Mater Sci Nanotechnol


Efficient dual targeted chemotherapy is an attractive approach for killing the tumor cells and tumor endothelial cells, while sparing the normal tissue. Herein, we investigated whether encapsulation of paclitaxel (PTX) within polymer– lipid hybrid nanoparticles conjugated with kNGR (PLNs-kNGR) achieved this goal in a subcutaneous tumor induced Balb/c mice bearing HT-1080 tumor model with nanocarrier-modified biodistribution and toxicity. The dual targeted PLNs-kNGR was prepared by modified nano-precipitation technique combined with self-assembly and evaluated for different parameters. Compared with other tested NPs, PLNs-kNGR-NPs revealed more cytotoxicity by inducing more apoptosis, higher intracellular uptake and % tumor volume inhibition rate that was 59.7%. These findings substantiate the importance of rational design of nanoparticles for dual targeting synergistic therapy. As a consequence, the PLNs-kNGR-NPs play a key role in enhancing tumor therapeutic efficiency for treatment of CD13 receptor specific solid tumor.



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