Materials Science and Nanotechnology

Paclitaxel-loaded magnetic nanoparticles as a targeted drug delivery system

International Conference on Nanomaterials and Nanotechnology
October 29-30, 2018 | London, UK

Yu-Ming Wang

Chang Gung University, Taiwan

Posters & Accepted Abstracts : Mater Sci Nanotechnol

Abstract:

Paclitaxel, a microtubule-stabilizing antineoplastic cytotoxic drug, inhibits invasiveness of several cell types. In this work, an anticancer drug delivery system that combines magnetic nanoparticles with a layer-by-layers system will be proposed. The monodisperse superparamagnetic iron oxide (SPION) was prepared by thermal decomposition. The surface of the iron oxide particles was functionalized with a carboxyl group. Functionalized Fe3O4@TMS-EDTA combined with layer-bylayers system: Poly(l-lysine)/poly(l-glutamic acid) (PLL/PGA). Next, biotinylated paclitaxel is combined with Fe3O4@TMSEDTA/ PLL/PGA system. The system of Fe3O4@TMS-EDTA/PLL/ PGA/biotinylated paclitaxel has a strong antiangiogenic activity, a property that might contribute to its antineoplastic activity in vivo.

Biography:

Yu-Ming Wang is currently pursuing his master’s in graduate Institute of Biochemical and Biomedical Engineering of Chang Gung University, Taiwan. 

E-mail: yuming5331@gmail.com

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