Materials Science and Nanotechnology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-7360-538437

Paclitaxel-loaded magnetic nanoparticles as a targeted drug delivery system

International Conference on Nanomaterials and Nanotechnology
October 29-30, 2018 | London, UK

Yu-Ming Wang

Chang Gung University, Taiwan

Posters & Accepted Abstracts : Mater Sci Nanotechnol


Paclitaxel, a microtubule-stabilizing antineoplastic cytotoxic drug, inhibits invasiveness of several cell types. In this work, an anticancer drug delivery system that combines magnetic nanoparticles with a layer-by-layers system will be proposed. The monodisperse superparamagnetic iron oxide (SPION) was prepared by thermal decomposition. The surface of the iron oxide particles was functionalized with a carboxyl group. Functionalized [email protected] combined with layer-bylayers system: Poly(l-lysine)/poly(l-glutamic acid) (PLL/PGA). Next, biotinylated paclitaxel is combined with [email protected]/ PLL/PGA system. The system of [email protected]/PLL/ PGA/biotinylated paclitaxel has a strong antiangiogenic activity, a property that might contribute to its antineoplastic activity in vivo.


Yu-Ming Wang is currently pursuing his master’s in graduate Institute of Biochemical and Biomedical Engineering of Chang Gung University, Taiwan. 

E-mail: [email protected]

Get the App

Vizag Tech Summit