+44 1400 530055Orthostatic tolerance and results of Autonomic testing in children with Migraine with and without Aura
Joint Event on 15th World Congress on Pediatrics, Clinical Pediatrics and Nutrition & 28th International Conference on Nursing Practice
November 28-29, 2018 | Dubai, UAE
Aleksandra Gergont, Sławomir Kroczka and Marek Kacinski
Jagiellonian University, Poland
Scientific Tracks Abstracts : Curr Pediatr Res
Abstract:
Background: Symptoms and signs of autonomic nervous system
(ANS) dysfunction and orthostatic intolerance are common in
patients with migraine. Despite the clinical signs of involvement
of ANS in the pathophysiology of migraine, the mechanism
of autonomic dysfunction was not fully explained. One of the
methods to establish a sympatho-vagal balance is examination
low frequency (LF) and high frequency (HF) spectrum of heart
rate variability.
Aims: The aim of the study was to establish LF/ HF ratio in
children with migraine (without and with aura) during an
orthostatic challenge. Prospective research, approved by
Bioethical Commission of Jagiellonian University.
Material and methods: The examination was performed in 86
children with migraine during a headache-free period and in 32
children without headaches and syncope, constituting an agematched
control group. HRV was evaluated during rest, during
a 10-min 70 degrees head-up passive tilting and during 3-min
active standing test, using Task Force Monitor 3030i/3040i.
Results: In all 47 children with migraine with aura head-up tilt
test was negative for syncope. In 2/39 children with migraine
without aura and in 2 controls head-up tilt-induced syncope
occurred. Postural orthostatic tachycardia syndrome (POTS)
was diagnosed in 4/24 children with migraine with sensory
aura and in 1 child with migraine without aura. Results of LF/
HF ratio did not differ between groups with migraine with aura
and controls, but they were significantly higher in group of 24
children with migraine with sensory aura during tilting.
Conclusions: Predominance of sympathetic nervous system
activity during tilting, as well as more common POTS in patients
with migraine with sensory aura as compared with healthy
volunteers and patients with migraine without aura, indicate
differential autonomic reactivity. In spite of poor orthostatic
tolerance reported by patients with migraine, active standing
did not reveal differences between migraine patients and
healthy volunteers.
Biography:
Aleksandra Gergont is a certified specialist in neurology and child neurology. She has completed her PhD from the Jagiellonian University in Krakow, Poland which is one of the oldest Universities in Europe. She is active in teaching and mentoring. In addition to education, she practices clinical pediatric neurology. She also conducts clinical research and is focusing upon dysfunction of autonomic nervous system. She directs autonomic laboratory at the Department of Pediatric Neurology, where she performs cerebrovascular Doppler examination and head-up tilt tests. Her research interests have been focused primarily on migraine, syncope and rare diseases, as well as vascular disorders. She is a member of Polish Child Neurology Association and she holds leadership position in its regional branch in Krakow. She is also a member of Polish Society of Clinical Neurophysiology. She is not only author and co-author of several publications but also reviewer.
E-mail: agergon@cm-uj.krakow.pl
PDF HTML