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Neoantigen discovery in non-small cell lung cancer
Joint Event on Global Experts Meeting on STD-AIDS and Infectious Diseases & 12th International Conference on Allergy, Immunology and Rheumatology
November 21-22, 2019 | Singapore
Asma Khanniche
Shenzhen Institutes of Advances Technology, China
Posters & Accepted Abstracts : J Infectious Disease Med Microbiol
Abstract:
Advances in next generation sequencing and bioinformatics have allowed the prediction and the identification of neoantigens that are endowed with exquisite tumor specificity and ability to induce T cell reactivity, which render them promising targets for cancer immunotherapies. Herein, taking into consideration the prevalence of the HLA-A0201 allele, we aimed at identifying a set of HLA-A0201 restricted neoantigens in NSCLC patients and evaluating their immunogenicity and specificity. Results showed the presence of immunogenic neoantigens; derived form genes such as TP53 and CDH10, etc. that are experimentally good binders with high affinity and ability of inducing a T cell response in vitro as compared to their WT counterparts suggesting a higher immunogenicity and specificity. These findings warrant more investigation of the therapeutic applications of these neoantigens aiming at enhancing anti-tumor immunity.
Biography:
E-mail: asmakhanniche@hotmail.com
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