Nano-biotechnology strategies and engineering design approaches towards the development of smart therapeutics biomaterials against infectious diseases
13th Annual Conference on Materials Science, Metal and Manufacturing
November 16-17, 2017 Paris, France
J Ruben Morones-Ramirez
Universidad Autonoma de Nuevo Leon, Mexico
Keynote : Mater Sci Nanotechnol
There is a growing need to enhance our antibacterial arsenal given the rising incidence of antibiotic resistance, the emergence of novel virulent pathogens, and the almost 40-year innovation gap between introductions of new molecular classes of antibiotics. In the face of newly infectious organisms and the global crisis in antibiotic resistance, there is a need to invigorate the basic science and technology of antimicrobial development. This work, describes different engineering approaches to resolve some of the challenges in antibiotic development. The first approach involves exploring potentiation of current antibiotics using novel and naturally existing therapeutic adjuvants (such as silver and supplementary metallic micronutrients) based on a better understanding of the mechanisms of infectious disease, a comprehension of microbe-therapeutic biochemical interactions as well as the microbial genetic responses to therapeutics. The second approach includes some of the work in progress to develop novel drug delivery systems, using the interface of Nanotechnology and Synthetic Biology, to design intelligent and endogenous antimicrobial therapeutics. The final approach addresses the commitment to discover novel antimicrobial molecules and therapies. This work, in the third approach, describes an innovative mechanism to discover antimicrobial molecules through the identification of fruitful competitive biochemical interactions between a set of microorganisms in synthetic and natural ecologies. Recent Publications â¢ JR Morones-Ramirez, JA Winkler, CS Spina, and JJ Collins (2013) Silver enhances the activity and broadens the spectrum of antibiotics against Gramnegative bacteria. Science Translational Medicine. 5: 190ra81. (2013) â¢ S Kalghatgi, CS Spina, JC Costello, M Liesa, JR Morones-Ramirez, S Slomovic, A Molina, OS Shirihai, and JJ Collins (2013) Clinically relevant doses of bactericidal antibiotics induce oxidative damage in mammalian cells via a common mechanism. Science Translational Medicine. 5: 192ra85. â¢ JR Morones-Ramirez (2014) Coupling metallic nanostructures to thermally responsive polymers allow the development of intelligent responsive membranes. International Journal of Polymer Science. 2014: 1-7. â¢ Garza Gonzalez MT, Barboza Perez D, Vazquez Rodriguez A, Garcia-Gutierrez DI, Zarate X, CantÃº Cardenas ME, Urraca-Botello LI, LopezChuken UJ, Trevino-Torres AL, Cerino-CÃ³rdoba FJ, Medina-Ruiz P, Villarreal-Chiu JF, JR MoronesRamÃrez (2016) Metal-induced production of a novel bioadsorbent exopolysaccharide in a native Rhodotorula mucilaginosa from the Mexican Northeastern region. PLoS One. 11(2): e0148430.