+441518081136Is human papillomavirus associated with Breast Cancer or papilloma presenting with pathologic nipple discharge?
14th International Conference on Cancer and Cancer Therapy
December 05-06, 2019 | Dubai, UAE
Fatih Levent Balci, Cihan Uras and Sheldon Feldman
Duke University Medical Center, USA
Posters & Accepted Abstracts : J Med Oncl Ther
Abstract:
Purpose: There are little data on the presence or interaction
of human papillomavirus (HPV) in intraductal papilloma
or Breast cancer (BC) presenting with pathologic nipple
discharge (PND). The study aimed to de- termine whether the
HPV-genotypes are identifiable in papilloma or carcinoma of
the breast by real-time PCR with broad-spectrum genotyping.
Methods: Formalin-fixed-paraffin-blocks obtained from
the patients who were suffering from PND and underwent
ductoscopic papilloma extraction (n=27) or segmental/
total mastectomy for cancer diagnosis (n=18). HPV-DNAs
were identified by PCR with broad-spectrum genotyping.
Mc Nemar test was used to compare cancer involved
cases to normal-adjacent tissue concerning HPV positivity.
Chi-Square test was used to analyze the association for
receptor status in HPV positive cancer involved cases.
Results: The mean age ( ± SD) was 49 ± 16 in papilloma and
52 ± 14 in BC patients, respectively. We found high prevalence
of HPV in papilloma and carcinoma: 29.6% (n=8) and 44.4%
(n=8), respectively. The most common type identified in
breast lesions was HPV-11 and the others were HPV- 6, 11,
39 and 82. Cancer involved samples were more contaminated
by HPV in comparison to normal-adjacent tissues (p=0.016).
In HPV positive cancer involved cases, hormone receptors
were found to be more positive than HER2-Neu (p=0.035).
Conclusions: Our data suggest that HPV might be a causative
agent for the development of papilloma and carcinoma of
the breast in some cases presenting with PND. HPV positive
breast cancers are more likely to be hormone positive. Further
studies needed for validation regarding the integration of
HPV-DNAs into the human genome that causes BC.
Biography:
E-mail:
fatihleventbalci@gmail.comPDF HTML