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Glycation injury effects on aging and possible ways of prevention
World Congress on DERMATOLOGY RESEARCH
April 22, 2022 | Webinar
Fatema Tasnim
Center for the Women of New York, United States
Posters & Accepted Abstracts : Dermatol Res Skin Care
Abstract:
Glycation is both a physiological and pathological process which mainly affects proteins, nucleic acids and lipids. Exogenous and endogenous glycation produces deleterious reactions that take place principally in the extracellular matrix environment or within the cell cytosol and organelles. Advanced glycation end product (AGE) formation begins by the non-enzymatic glycation of free amino groups by sugars and aldehydes which leads to a succession of rearrangements of intermediate compounds and ultimately to irreversibly bound products known as AGEs. Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and peptides/proteins are an important part of the aging process in humans. Recent studies have revealed the contributing roles of AGEs in the development of various aging-related conditions, such as diabetes, heart disease and cancer. It is known that physical exercise improves the lipid profile, insulin resistance and reduces the risk of cardiovascular diseases. Controlling the blood sugar level is a natural method to inhibit glycation in diabetes. A large number of plants and natural biomolecules have been shown to have antidiabetic effects too. It is also seen from animal studies that exercise reduces the concentration of AGEs and highly reactive intermediates of AGE. So, it can be stated that glycation can be prevented by the natural defense mechanisms in the body, synthetic and natural inhibitors. Recent Publications 1. Gladyshev VN. On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan. Bioessays. 2012;34:925–9. 2. Gladyshev VN. The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. Trends Genet. 2013;29:506–12. 3. Kim, C. S., Park, S., & Kim, J. The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise. Journal of exercise nutrition & biochemistry, 2017, 21(3), 55–61.
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