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Gardner diamond syndrome: A systematic review of treatment options
Spring Dermatology & Skin Care Expo Conference
May 14-15, 2018 | Montreal, Canada
Megan Block
Creighton University School of Medicine, USA
Posters & Accepted Abstracts : Dermatol Res Skin Care
Abstract:
Gardner Diamond Syndrome (GDS), also referred to as auto-erythrocyte sensitization syndrome or psychogenic purpura, is a rare psych dermatological condition characterized by the formation of spontaneous, painful skin lesions that develop into ecchymosis following episodes of severe physiological or psychological stress. The majority of GDS cases occur in young adult females and although the etiology of this rare disorder is unknown, there appears to be a psychological component correlated with the co-existence of previous psychiatric diagnoses. Due to the rare nature of this disorder, there exist few guidelines for prompt clinical diagnosis and optimal treatment. Here, a systematic review was conducted to include 45 international cases of patients with GDS to better understand clinical presentation as well as current treatment options. Ultimately, GDS is a diagnosis of exclusion after other coagulopathies and causes of purpura are ruled out. High clinical suspicion following laboratory and clinical exclusion of known physiological causes is necessary for diagnosis. Selective serotonin reuptake inhibitors (SSRIs) and corticosteroids are cost effective first line treatments for GDS with proven efficacy in symptomatic relief. GDS refractory to initial treatment may require regular psychotherapy and titrated SSRI dosages to achieve longterm success. This review of available case studies serves to comprehensively describe the clinical presentation and available treatment approaches to this rare disorder. e: MeganBlock@creighton.edu
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