Direct evidence of viral infection and mitochondrial alterations in the brain of fetuses at high risk for schizophrenia
Annual Congress on Cell Science, Stem Cell Research & Pharmacological Regenerative Medicine
November 29-30, 2017 | Atlanta, USA
Segundo Mesa Castillo
Psychiatric Hospital of Havana, Cuba
Keynote : Adv cel sci tissue cul
Introduction: There are increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point toward intra-uterine environmental factors that act specifically during the second pregnancy trimester producing a direct damage of the brain of the fetus. The current available technology doesn’t allow observing what is happening at cellular level since the human brain is not exposed to a direct analysis in that stage of the life in subjects at high risk of developing schizophrenia. Methods: In 1977, we began a direct electron microscopic research of the brain of fetuses at high risk from schizophrenic mothers to find differences at cellular level in relation to controls. Results: In these studies, we have observed within the nuclei of neurons the presence of complete and incomplete viral particles that reacted in positive form with antibodies to herpes simplex hominis type I [HSV1] virus and mitochondria alterations. Conclusion: The importance of these findings can have practical applications in the prevention of the illness keeping in mind its direct relation to the etiology and physiopathology of schizophrenia. A study of amniotic fluid cells in women at risk of having a schizophrenic offspring is considered. Of being observed the same alterations that those observed previously in the cells of the brain of the studied fetuses, it would intend to these women in risk of having a schizophrenia descendant, previous information of the results, the voluntary medical interruption of the pregnancy or an early anti HSV1 viral treatment as preventive measure of the later development of the illness.
Segundo Mesa Castillo worked for 10 years as Specialist in Neurology in the Institute of Neurology of Havana, Cuba. He has worked in Electron Microscopic Studies on Schizophrenia for 32 years. He was awarded with the International Price of the Stanley Foundation Award Program and for the Professional Committee to work as a Fellowship position in the Laboratory of the Central Nervous System Studies, National Institute of Neurological Diseases and Stroke under Joseph Gibbs for a period of 6 months, National Institute of Health, Bethesda, Maryland, Washington DC, USA, June 5, 1990. At present, he is a Member of the Scientific Board of the Psychiatric Hospital of Havana and gives lectures to residents in Psychiatry.