Determination of the role of HA, HYAL and HA- Receptor Expression in a rat model of Middle Cerebral Artery Occlusion

Determination of the role of HA, HYAL and HA- Receptor Expression in a rat model of Middle Cerebral Artery Occlusion

13^th International Conference on Alzheimers Disease and Dementia
November 25-26, 2019 | Frankfurt, Germany

Ahmed Al Qteishat

Al-Ahliyya Amman University, Jordan

Scientific Tracks Abstracts : J Psychol Cognition

Abstract:

Hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating angiogenesis and cell proliferation, migration, and signaling. We used the rat MCAO to show hyaluronan accumulation in stroke-affected areas. Using RT-PCR and Western blotting we showed up-regulation of hyaluronidase-1 and 2 between 1h and 21 days after stroke. Hyaluronidase-1 was up regulated earlier than hyaluronidase-2. RHAMM and CD44 receptors were also increased after stroke. Immunohistochemistry results, showed an association of hyaluronidases1/2 and hyaladherins with neurons in the infarcted and peri-infarcted regions and hyaluronidase-1 with microvessels. HA synthesis and degradation in the stroke hemisphere might have an impact on neuronal survival, angiogenesis and general tissue remodeling after stroke.

Biography:

Ahmed Al Qteishat is currently working as an associate professor in Al- Ahliyya Amman University, Amman, Jordan. He studied his Bachelor degree in the Applied Science University. He completed his Ph.D in Manchester Metropolitan University.

E-mail: a.qteishat@ammanu.edu.jo

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