Degenerative osteoarthritis a reversible chronic disease

Degenerative osteoarthritis a reversible chronic disease

6^th World Congress and Expo on Cell and Stem Cell Research
March 16, 2022 | Webinar

Valerio Di Nicola

University Hospitals Sussex, UK

Scientific Tracks Abstracts : Adv cel sci tissue cul

Abstract:

Osteoarthritis (OA) is the most common chronic musculoskeletal disorder. It can affect any joint and is the most frequent single cause of disability in older adults. OA is a progressive degenerative disease involving the entire joint structure in a vicious circle that includes the capsulebursa tissue inflammation, synovial fluid modifications, cartilage breakdown and erosions, osteochondral inflammatory damage leading to bone erosion and distortion. Research has identified the initial inflammatory-immunologic process that starts this vicious cycle leading to so-called early OA. Research has also identified the role played in the disease advancement by synoviocytes type A and B, chondrocytes, extracellular matrix, local immune-inflammatory mediators and proteases. This article investigates the joint-resident MSCs that play an essential local homeostatic role and regulate cell turn over and tissue repair. Resident MSCs establish and maintain a local regenerative microenvironment. The understanding of OA physiopathology clarifies the core mechanisms by which minimally invasive interventions might be able to halt and reverse the course of early-stage OA. Interventions employing PRP, MSCs and exosomes are considered in this presentation.

Biography:

Valerio Di Nicola (VDN) is a surgeon and researcher currently working as consultant in general, emergency, and lower GI Surgery and lead of research and surgical audit at University Hospitals Sussex (UHSussex), NHS Foundation Trust- Worthing Hospital- BN112DH (UK). Further, he is the scientific director of the Regenerative Surgery Unit (RSU), Villa Aurora Hospital-Foligno-Italy. VDN started his career in regenerative medicine research during his PhD in microsurgery (1994-1999) at the Policlinico Umberto I - “Sapienza” University of Rome (Italy). From May 2013 to June 2015, VDN was scientific director of the Interbion Foundation for Basic Biomedical Research. Montedato, CH- 6595 Riazzino, Switzerland. VDN has recently presented to various international conferences and published his new model of care delivered by the Regenerative Surgery Unit (RSU).

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