+44-1518-081136Bio-functionalized colloidal nanoparticles for therapeutic applications
Joint Event on 2nd International Conference on Nanomaterials and Nanotechnology & 22nd International Conference on Advanced Nanoscience and Nanotechnology
May 16-17, 2019 | Prague, Czech Republic
Miriam Colombo
University of Milano-Bicocca, Italy
Keynote : Mater Sci Nanotechnol
Abstract:
Multifunctional nanoparticles are promising bimodal
tracers for noninvasive diagnosis and treatment of
cancer and inflammatory diseases in vitro and in vivo. The
design of bio-functionalized colloidal nanoparticles needs
careful optimization of size and shape, optical and magnetic
properties, and efficient conjugation with homing ligands
to improve the signal amplification and target selectivity
toward malignant cells. One of the greatest challenges in
designing nanoparticles functionalized with homing peptides
and proteins to optimize molecular recognition resides in
the possibility to finely control the ligand orientation on the
nanoparticle surface.
To support the research in new drug delivery nanosystems,
in the past few years new administration methods of
nanoparticles rather than traditional intravenous ones
have been explored. This is a highly innovative approach
that is nearly unexplored at present. Because of parenteral
administration draw-backs, alternative administration routes
have been investigated. Among all, the oral and topical
administration are the most interesting to obtain a local effect
and gain a better patient’s compliance.
Biography:
Miriam Colombo obtained her master’s degree in 2008 in Medicinal Chemistry and Technology at the University of Milano with experimental thesis in the Nanobiotechnology and she made the PhD in Biology in 2012 at the University of Milano-Bicocca. In 2010, she worked in the lab of prof. W. Parak, Marburg, Germany. In January 2009, she was awarded of a 12+24 months fellowship in the field of Medical Sciences. From September 2013, she is a researcher in clinical biochemistry (BIO/12), at the Department of Biotechnology and Bioscience of University of Milano- Bicocca. She is author of 70 scientific publications on peer-reviewed international journals and official H-Index (Scopus): 22.
E-mail: Miriam.colombo@unimib.it
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