+441518081136Aortic stiffness and older age predict sharper cognitive performance decline in the Elsa-Brasil Cohort
13th International Conference on Alzheimers Disease and Dementia
November 25-26, 2019 | Frankfurt, Germany
Sandhi Maria Barreto
Universidade Federal de Minas Gerais, Brazil
Scientific Tracks Abstracts : J Psychol Cognition
Abstract:
Background and Purpose: Aortic stiffness has been
associated with cognitive decline and dementia, but
the results are inconsistent. This study investigated the
longitudinal association of aortic stiffness and age with
decreased cognitive performance in three cognitive tests.
Methods: We included 6,927 participants (mean age
58.8 years) without cerebrovascular disease or cognitive
impairment at baseline (2008-2010) who participated at the
2nd wave (2012-2014) of the ELSA-Brasil (interval between
visits ranging from 2-6 years). Cognitive performance was
evaluated by memory, phonemic and semantic verbal
fluency, and trail-B tests, applied at both cohort visits.
Associations with the carotid femoral pulse wave velocity
(cf-PWV) and age at baseline were investigated using linear
models with mixed effects after adjusting for confounders.
Results: After all the adjustments, including for systolic blood
pressure, the interaction term cf-PWV*time was statistically
significant for memory and verbal fluency tests, indicating
that the higher the cf-PWV at baseline the faster the decline
in cognitive performance in these tests in the 2nd wave.
The interaction term age*time was statistically significant
for all cognitive tests, suggesting that increasing age at
baseline was also associated with a faster decline in cognitive
performance between waves.
Conclusion: In this relatively young cohort, and after a
relatively short interval, an increased aortic stiffness at
baseline was associated with a sharper decline in cognitive
performances in memory and verbal fluency, independently
of systolic blood pressure levels. We also showed that the
decline in cognitive performance was faster among older
individuals than younger ones at baseline.
Biography:
Sandhi Maria Barreto is currently working in Universidade Federal de Minas Gerais, Brazil. She has studied her masters in Brazil. She did many researches in neuroscience field.
E-mail: sandhi.barreto@gmail.com
PDF HTML