+1 (629)348-3199Acute-on-chronic liver failure (ACLF)
World Liver Conference 2018
May 25-26, 2018 | New York, USA
Salem Y Mohamed
Zagazig University, Egypt
Posters & Accepted Abstracts : J Gastroenterol Dig Dis
Abstract:
Acute on chronic liver failure (ACLF) is a distinct clinical syndrome characterized by liver failure due to an acute hepatic injury on an underlying chronic liver disease with high 28-day mortality. Acute insults include alcohol, hepatotropic viruses, and drugs whereas the underlying chronic liver disease is cirrhosis due to alcohol, hepatitis B or C, or NASH. After an acute insult, persistent inflammation, systemic inflammatory response syndrome and the cytokine storm have a central role in the pathogenesis of liver failure and subsequent organ failure. Abstinence, antiviral therapy, and withdrawal of harmful drug are specific therapies that could help ameliorate or reverse the liver failure. Liver transplantation is the definitive treatment, and a good outcome is achieved with early transplantation in carefully selected patients; liver dialysis and plasmapheresis can help as ‘bridge therapies.' What about the magnitude of the problem in the Middle East and Africa? Is there any difference between the definitions of ACLF, risk factors, and presentations in different parts of the world? e: salemyousefmohamed@gmail.com
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