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Journal of Timely Topics in Clinical Immunology | Volume 2

July 26-28, 2018 | Moscow, Russia

Immunology

Annual Congress on

The Immunology of pregnancy

Akinyemi Ayodeji Akinsanya

Hospital Igbobi-Lagos, Nigeria

regnancy is an immunological balancing act in which

the mother’s immune system has to remain tolerant of

paternal major histocompatibility (MHC) antigens and yet

maintain normal immune competence for defense against

microorganisms. The placenta separates fetal and maternal

bloodand lymphatic systems and it is fetal trophoblast that plays

the major role in evading recognition by the maternal immune

system. Trophoblast cells fail to express MHC class I or class II

molecules and the extravillous cytotrophoblast cells strongly

express the nonclassic MHC gene encoding HLA-G, which may

downregulate natural killer (NK) cell function. In addition, the

trophoblast expresses Fas ligand, thereby conferring immune

privilege: maternal immune cells expressing Fas will undergo

apoptosis at the placenta/decidua interface. A third protective

mechanismexploited by the trophoblast is the expression of the

complement regulatoryproteinsCD46, CD55, andCD59.Uterine

decidual and placental cells produce a huge array of cytokines

which, in part, contribute to the deviation of the immune

response fromTh1 toTh2. Thismay leave themothermoreopen

to infection whose control is Th1-dependent, but increased

production of Th1 cytokines has been linked to spontaneous

abortion and small-for-dates babies. This bias in cytokines and

hormonally mediated effects on the thymus and on B cells may

also contribute to the suppression of autoimmune responses

and changes in circulating and local T-cell subsets in pregnancy.

Speaker Biography

Akinyemi Ayodeji Akinsanya American medical educator, physician, consultant. He did

his scholar in University lagos,2008 and Proceeds to Newcastle University Medicine

Malaysia to earn his doctorate. Bachelor of Science with honors, University of Lagos

Bachelor of Medicine Bachelor of Science with honors, Doctor of Medicine, Newcastle

University Medicine Malaysia 2012. Currently, working as a Medical resident health

Hospital igbobi lagos and lecturer I Lagos state university junior lecturer, 2017.